Professor Tommy Cheng Yung Chi

Professor Tommy Cheng Yung Chi

Personal Data
Date of Birth:	December 29, 1944
Place of Birth:	Great Britain
Citizenship:	USA
Marital Status:	Married, to Elaine HC Cheng
Number of Children:	Two
Home Address:	961 Baldwin Road, Woodbridge, CT

Education
Institution	Subject & Degree	Year
Tunghai University, Taiwan Republic of China	Chemistry B.S.	1966
Brown University Providence, RI	Biochemical Pharmacology Ph.D.	1972

POSTDOCTORAL TRAINING
6/72 8/72	Research Associate, Section of Biochemical Pharmacology, Brown University, Providence, Rhode Island with Dr. R.E. Parks.
9/72 6/73	Postdoctoral Research Staff, Pharmacology Department, School of Medicine, Yale University, New Haven, Connecticut with Dr. W.H. Prusoff.

POSITIONS HELD
7/90-Present	Program Director, Developmental Therapeutics/Chemotherapy, Yale Comprehensive Cancer Center, New Haven, CT.
7/89 Present	Henry Bronson Professor of Pharmacology, Yale University School of Medicine, New Haven, CT.
6/89 Present	Professor of Pharmacology and Internal Medicine, Yale University School of Medicine, New Haven, CT.
7/79 6/89	Head, Drug Development Program, Lineberger Cancer Research Center, University of North Caroli¬na, School of Medicine, Chapel Hill, NC.
4/79 6/89	Professor, Departments of Pharmacology and Medicine, University of North Carolina, School of Medicine, Chapel Hill, NC.
2/87 12/87	Special Chair, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, Republic of China.
9/77 4/79	Cancer Research Scientist V, Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, NY.
6/77 4/79	Associate Professor, Department of Pharmacology, Roswell Park Division of the Graduate School, State University of New York, Buffalo, NY.
6/76 9/77	Associate Cancer Research Scientist, Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, NY.
9/74 6/77	Assistant Professor, Department of Pharmacology, Roswell Park Division of the Graduate School, State University of New York, Buffalo, NY.
9/74 6/76	Senior Cancer Research Scientist, Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, NY.
7/73 7/74	Research Associate (equivalent to Research Assistant Professor), Department of Pharmacology, Yale University School of Medicine, New Haven, CT.

PROFESSIONAL SOCIETIES:
1. American Association for Cancer Research
2. Member of Sigma XI
3. American Microbiology Society
4. American Society of Pharmacology and Experimental Therapeutics
5. American Society of Biological Chemistry
6. American Association for the Advancement of Science
7. American Society for Clinical Pharmacology and Therapeutics
8. Society of Chinese Bioscientists in America
9. The Protein Society

HONORS:
1. American Leukemia Society Scholar 1976-1981
2. Rhoads Memorial Award, American Association of Cancer Research 1981
3. Outstanding Alumni Award, Brown University, Providence, RI 1990
4. Honorary Professor, Beijing Medical University, Beijing, China 1991
5. Honorary Professor, Union Medical University and CAMS, Beijing, China 1992
6. Outstanding Award in Bio-Medical Science, SCBA 1992
7. Member, Academia Sinica, Republic of China 1994
8. Outstanding Investigator Award, National Cancer Institute 1987 1997
9. Honorary Vis Sci, Institute of the Advancement of Chinese Medicine, Hong Kong, Chinese University, Hong Kong 1998
10. Member, Connecticut Academy of Science and Engineering 1998
11. 1999 ASPET Award (Am Soc Pharm and Exp Therap) 1999
12. Honorary Professor, Harbin Medical University, China 1999
13. National Foundation for Cancer Research Fellow 2000-2010
14. Distinguished Alumni Award, Tunghai University, Taipei, Taiwan 2001
15. Honorable Professor, Zhejiang University, Hangzhou, China 2001
16. Outstanding Achievement Award, Chinese/American Acad Prof Soc 2002
17. Honorable Professor, School of Medicine, University of Hong Kong 2002
18. Honorary Professor , Institute of Material Medica, Chinese Academy of Science 2003
19. Presidental Award, Society of Chinese Bioscientists in America 2004
20. BMRC Distinguished Visitor, Singapore 2005
21. Distinguished Visiting Professor, The University of Hong Kong 2005
22. Honorary Chair Professor, Chinese Medical University, Taiwan 2007
23. Honorary Professor, Xiamen University 2008
24. Honorary Professor Yunan Medical College 2008

EXTRAMURAL COMMITTEES SERVED

BUSINESS:
1. Consultant, Antivirus Program, Syntex Inc. 1981-1988
2. Consultant, Boehringer Ingelheim Pharmaceuticals 1990-1994
3. Consultant, Antivirus Program, Bristol-Myers, Inc. 1986 1991
4. Member, Sci. Advis. Bd., G.D. Searle Pharmaceutical Co 1981-1986
5. Member, Burroughs Wellcome Fund Task Force, NC 1985
6. President, Society of Chinese Bioscientists in America 1987
7. Member, Scientific Advisory Board, Genelabs, Inc. 1991-1994
8. Consultant 1988-1998
9. Consultant, Boehringer Ingelheim Pharmaceuticals 1990-1994
10. Consultant, DuPont Pharmaceuticals 1989-1993.
11. Consultant, Antivirals, Wyeth-Ayerst Laboratories 1988-1994
12. Member and Co-Chairman, Scientific Advisory Board, Sparta Pharmaceuticals 1990-1998
13. Consultant, Antivirus Program, Bristol-Myers, Inc. 1986 1991
14. Member, Scientific Advisory Board, G.D. Searle Pharm. Co. 1981-1986
15. Member, Scientific Advisory Board, U.S. Bioscience 1991-1998
16. Member, Sci Advis. Bd., MicroProbe, Inc. 1991-1994
17. Consultant, Antivirus Program, Syntex Inc. 1981-1988
18. Member, Scientific Advisory Board, HEM Pharmaceuticals 1991-1996
19. Chairman of the Board, Division of Bio/Pharm, SCBA 1994-1997
20. Member, Scientific Advisory Board, Vion Pharmaceutical 1995-2007
21. Consultant, Biochem Pharma 1996-2002
22. Director, Board of Directors, Response Biomedical Board, Vancouver, B.C 1997-2000
23. Member, Scientific Advisory Board, Triangle Pharmaceuticals 1998-2000
24. Consultant, Triangle Pharmaceuticals 2000-2003
25. Scientific Founder/Chairman, Scientific Advisory Board, Phytoceutica 1999-Present
26. Consultant in Chinese Medicine, New World Development, HK 1999-2000
27. Scientific Founder/Chairman, Scientific Advisory Board, Achillion 2000-2006
28. Consultant, Oncolys BioPharma, Inc. 2007-Present
29. Chairman, Consortium for the "Globalization of Chinese Medicine" (CGCM) 2006-Present
30. Member, Sci Adv Bd, FINOVI "Foundation Innovations en Infectiologie" 2006-Present
31. Consultant, Triangle Pharmaceuticals 2000-2003
32. Scientific Founder/Chairman, Scientific Advisory Board, Phytoceutica 1999-Present
33. Consultant in Chinese Medicine, New World Development, HK 1999-2000
34. Scientific Founder/Chairman, Scientific Advisory Board, Achillion 2000-2006
35. Consultant, Oncolys BioPharma, Inc. 2007-Present

ACADEMIC and GOVERNMENT:
1. Chairman, Study Section of Experimental Therapeutics, NCI/ NIH 1983-1984
2. Member, Board of Scientific Counselors, Division of Cancer Treatment, NCI/NIH 1986-1990
3. Member, Study Section of Experimental Therapeutics, NIH 1980-1984
4. Member, External Advisory Board of Wisconsin Clinical Cancer Center, Madison 1984-1986
5. President, Society of Chinese Bioscientists in America 1987
6. Chairman, Gordon Research Conf "Purines, Pyrimidines, and Related Compounds 1984
7. Chairman, Biochemistry Section, Annual Meeting of the AACR 1987
8. Chairman, AACR Clowes Award Subcommittee 1988
9. Chairman, Study Section of the Biopharmaceutical Science, NHRI 1994-1997
10. Member, AIDS Research Advisiory Committee, NIAID, NIH 1991-1994
11. Chairman of the Board, Bio/Pharm Division SCBA 1994-1997
12. Member, Board of Scientific Counselors, National Health Research Institute, Taiwan 1995–Present
13. Chairman, Action Committee for Med. Biotech., Academia Sinica 1996-1999
14. Chairman, Advisory Committee for Med. Biotech. Academia Sinica 1999-2001
15. Special Advisor to the Committee for the Biotechnology Industry Under Executive Yuan, Taiwan 1996-2000
16. Panel Member of Biomedical Science. University Grant Committee, Hong Kong 1996-2003
17. Consultant, The Hong Kong University of Science & Technology 1999-Present
18. Chairman, International Advisory Board for Bio/Pharm Division (SCBA) Sponsored Herbal Medicine Symposium (1) Toronto, 1997); (2) Hong Kong, 1998; (3) Taiwan, 2000; and (4) Shanghai, 2004. 1999-Present
19. Member Scientific Advisory Board – Beijing Nat’l Biochip Research and Engineering Center 2001-Present
20. Chairman, Steering committee for program of Chinese Medicine, Hong Kong University 2002-Present
21. Chief Consultant, Program of Chinese Medicine, Shanghai Institute of Life Sciences, Chinese Academy of Science 2002-Present
22. Chief Consultant, Program of Chinese Medicine, Chinese Acad Med Sci (CAMS) 2003-Present
23. Ad hoc Member, National Advisory Council for CAM/NIH, USA 2005
24. Chairman, Consortium for “Globalization of Chinese Medicine” (CGCM) 2003-Present
25. Chief Consultant and Advisor for Biotech/Pharm, Yunnan Province 2007-Present
26. Chairman, Sci Adv Bd, Agriculture Biotech Ctr, Academia Sinica 2008-Present
27. Member, Sci Adv Bd, FINOVI Foundation Innovations en Infectiologie 2008-Present
28. Member, International Advisory Board TCM Research Center, Graz, Austria 2009-Present
29. Co-Chairman, Advisory Board GP-TCM Advisory Board, London, UK 2010-Present

EDITORIAL BOARDS:
1. Associate Editor, Methotrexate Update, Lederle Laboratories 1983-1986
2. Editorial Board, Virus Genes, Martinus Nijhoff Publishing 1987-Present
3. Editorial Board, Cancer Communications, Pergamon Press 1989-Present
4. Associate Editor, Cancer Research, Waverly Press 1990-1995
5. Associate Editor, Biochemical Pharmacology, Pergamon Press 1990-2003
6. Advisory Board, J. Biomedical Science, Kerger Press 1995-Present
7. Advisory Board, Chinese Journal of Pharmacology & Toxicology 1995-Present
8. Advisory Board, Journal of Chinese Academy of Medical Science 1995-Present
9. Associate Editor, American Association for Cancer Research 2001-2003
10. Editorial Board, Molecular Cancer Therapeutics 2001-2005
11. Chinese Journal of Integrative Medicine (CJIM) 2007-Present
12. Int’l Society for Chinese Medicine (ISCM, Macao) 2009-Present
13. Advisory Board, Chinese Medicine Journal 2010-Present

RESEARCH INTERESTS: My interests are in the development of new drugs and the improvement of the use of clinically proven drugs for the treatment of cancer, and herpes virus, human immunodeficiency virus or hepatitis B virus associ¬ated diseases. The types of agents are deoxyribonucleoside analogs, folate analogs and compounds that interfere with DNA and RNA metabolism. Currently we are also interested in the potential uses of Chinese medicines. Therefore, we are studying:

1) The metabolism of nucleosides, oligonucleotides, folates and natural products in cell culture;
2) The properties of human or virus nucleoside, folate and DNA metabolizing enzymes;
3) Gene regulation of these enzymes in cells;
4) The behavior of nucleoside analogs, folate analogs, oligonucleotides and DNA metabolic targeting compounds toward these enzymes and cells;
5) The effects of these compounds on virus specific enzymes and virus replication;
6) The action of promising compounds on tumor growth in vivo;
7) The combined use of these agents with other agents, including collaterally sensitive compounds and Chinese medicines, and scheduling the drug for chemotherapy of cancer and virus induced diseases;
8) The mechanisms of drug toxicity, drug resistance and development of drug resistance;
9) The association of human tumors with herpes virus, hepatitis B and re¬trovirus; and
10) The biochemical behavior and genetic stability of tumor cells taken from patients.
11) The approaches in bringing Chinese Medicine into the mainstream of new medicine in the 21st century.
12) Discovery of anti-HIV, HBV and HCV chemicals with selectivity by targeting viral proteins.

PUBLICATIONS: Over 380 publications in Refereed Journals

DRUGS DISCOVERED There are three (3) drugs currently used in clinic. They were initially discovered in this laboratory. This includes:

o Gancyclovir - For Cytomegalo Viral infection
o Lamivudine - For Heapatitis B Virus infection
o Clevudine -- For Hepatitis B Virus infection

Three additional chemicals and one Chinese medicine formula were discovered and are currently at different stages of Clinical Trial for the treatment of cancer as well as HIV and HBV infection.

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